{"id":20387,"date":"2019-01-17T12:57:43","date_gmt":"2019-01-17T19:57:43","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=20387"},"modified":"2024-07-17T13:35:18","modified_gmt":"2024-07-17T19:35:18","slug":"can-stem-cells-heal-heart-failure-damage","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/can-stem-cells-heal-heart-failure-damage\/","title":{"rendered":"Can stem cells heal heart failure damage?"},"content":{"rendered":"<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div><p>In the waning days of 2003, Pete Hagerstrom suffered a heart attack that required quadruple bypass surgery at Memorial Hospital in Colorado Springs (now part of UCHealth). That was a life-changing event for him, of course, as it was for many others in 2003. Nearly <a href=\"https:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb281-Operating-Room-Procedures-During-Hospitalization-2018.jsp\" target=\"_blank\" rel=\"noopener noreferrer\">400,000 people in the United States<\/a> had coronary artery bypass procedures that year.<\/p>\n<p>Hagerstrom made a good recovery from the heart attack, but because of it he is now among the ranks of another large and growing population: <a href=\"https:\/\/www.cdc.gov\/heart-disease\/about\/heart-failure.html\" target=\"_blank\" rel=\"noopener noreferrer\">the 5.7 million people in the country<\/a> who have heart failure. Now, however, the 71-year-old Colorado Springs resident is one of a select group helping to study whether patients\u2019 own stem cells can strengthen their failing hearts.<\/p>\n<figure id=\"attachment_20389\" aria-describedby=\"caption-attachment-20389\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20389 size-medium\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124239\/EXT_121818_Pete-Hagerstrom.jpgeee.webp\" alt=\"a photo of Pete Hagerstrom at home in Colorado Springs\" width=\"300\" height=\"225\" srcset=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124239\/EXT_121818_Pete-Hagerstrom.jpgeee.webp 600w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124239\/EXT_121818_Pete-Hagerstrom.jpgeee-300x225.webp 300w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124239\/EXT_121818_Pete-Hagerstrom.jpgeee-150x113.webp 150w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124239\/EXT_121818_Pete-Hagerstrom.jpgeee-200x150.webp 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-20389\" class=\"wp-caption-text\">Pete Hagerstrom, at home in Colorado Springs, is the first patient at UCH to participate in the CardiAMP heart failure trial at UCH. He does not know whether he received bone marrow stem cells or not.<\/figcaption><\/figure>\n<p>The <a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02438306?term=cardiamp&amp;rank=2\" target=\"_blank\" rel=\"noopener noreferrer\">Phase 3 clinical trial <\/a>involves a therapy from San Carlos, California-based <a href=\"http:\/\/www.biocardia.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">BioCardia, Inc<\/a>. dubbed CardiAMP. It targets patients like Hagerstrom whose heart failure developed after a heart attack. These patients must also have significantly weakened left ventricles, as measured by their ejection fraction \u2013 a measure of the pumping strength of the heart \u2013 despite regular medication management and other treatments. Some 18 sites are participating, including <a href=\"https:\/\/www.uchealth.org\/locations\/uchealth-university-of-colorado-hospital-uch\/\">UCHealth University of Colorado Hospital<\/a> on the Anschutz Medical Campus. Hagerstrom is the first patient enrolled at UCH.<\/p>\n<h3><strong>Heal thyself<\/strong><\/h3>\n<p>The idea: extract blood from a patient\u2019s bone marrow, centrifuge it to separate the stem cells, and then use a catheterization procedure to deliver the cells to and inject them into ventricle tissue. The hope, which is strengthened by <a href=\"http:\/\/www.onlinejacc.org\/content\/72\/13_Supplement\/B299.1\" target=\"_blank\" rel=\"noopener noreferrer\">positive results in the previous trial phase<\/a>, is that the bone marrow stem cells will encourage growth of heart muscle cells called myocytes, said <a href=\"https:\/\/www.uchealth.org\/provider\/natasha-altman-md-advanced-heart-failure-and-transplant-cardiology\/\">Dr. Natasha Altman<\/a>, an advanced heart failure and transplant cardiology specialist who is principal investigator for the CardiAMP trial at UCH.<\/p>\n<p>\u201cThe theory has to do with utilizing the property of bone marrow stem cells to cause the cardiac myocytes to reproduce a little bit better and cause some strengthening of heart tissue,\u201d Altman said. \u201cThe stem cells are not becoming heart cells; they are helping heart cells develop again.\u201d<\/p>\n<p>The primary outcome measure for the trial is improvement in patients\u2019 six-minute walk distances 12 months after the procedure. \u201cWe want to see if patients feel better and can do more with the study treatment,\u201d Altman said.<\/p>\n<p>The study could offer new promise for patients like Hagerstrom, said <a href=\"https:\/\/www.uchealth.org\/provider\/john-messenger-md-interventional-cardiology\/\">Dr. John Messenger<\/a>, an interventional cardiologist at UCH and professor of medicine-cardiology at the University of Colorado School of Medicine. He is the\u00a0co-investigator with Altman for the CardiAMP trial. Messenger completed two days of training for the procedure and performed it on Hagerstrom last fall.<\/p>\n<p>\u201cIt\u2019s a very important project because it extends the treatment options we have for patients with heart failure after a myocardial infarction,\u201d Messenger said. He noted that as of now the only choices for patients whose low ejection fractions fail to improve with medications are left ventricular assist devices (LVADs) or heart transplants, but a large percentage of patients don\u2019t qualify for either of those.<\/p>\n<figure id=\"attachment_20388\" aria-describedby=\"caption-attachment-20388\" style=\"width: 214px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20388 size-medium\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124120\/tinyhagerstrom.webp\" alt=\"Dr. Natasha Altman leads the CardiAMP trial at UCH.\" width=\"214\" height=\"300\" srcset=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124120\/tinyhagerstrom.webp 700w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124120\/tinyhagerstrom-214x300.webp 214w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124120\/tinyhagerstrom-107x150.webp 107w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124120\/tinyhagerstrom-200x280.webp 200w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><figcaption id=\"caption-attachment-20388\" class=\"wp-caption-text\">Dr. Natasha Altman leads the CardiAMP trial at UCH.<\/figcaption><\/figure>\n<p>\u201cThis treatment might allow us to get people down the road without having to move on to more complicated mechanical support or transplant,\u201d Messenger said. \u201cIt\u2019s another tool that potentially opens the door to more patients.\u201d<\/p>\n<p>During the procedure in the cardiac catheterization lab, members of Altman\u2019s research team extract bone marrow from the crest of the patient\u2019s hip bone, then spin it rapidly to separate large numbers of pure stem cells. Messenger then threads a catheter bearing a corkscrew-like needle to the ventricle. His team uses echocardiography to locate areas of the ventricle that lie at the edges of scarred tissue, then Messenger inserts the needle into the vessel and injects the stem cells. After the procedure, the patient stays overnight at the hospital for observation while the team examines images of the heart to ensure the procedure didn\u2019t puncture the ventricle or cause any other issues.<\/p>\n<h3><strong>Hope \u2013 with caution<\/strong><\/h3>\n<p>There are several provisos for the study, Altman said. Patients who meet the initial inclusion criteria must have an echocardiogram and a bone marrow biopsy to determine the potency of the stem cells. BioCardia, she explained, uses an algorithm that projects the ability of the cells to sufficiently strengthen the heart muscle.<\/p>\n<p>Thus far, Altman said, about one-third of prospective trial patients nationally have been screened out. \u201cTheir stem cells were not strong enough to produce the effect in the heart tissue that we would hope,\u201d she said.<\/p>\n<p>In addition, the study is randomized. Roughly three in five who meet the screening criteria and undergo the procedure will actually receive the stem cells; two in five will go through all the same steps but will not get the treatment. Patients don\u2019t know which group they are in. At UCH, only Messenger knows who received the treatment and who did not.<\/p>\n<p>Hagerstrom is philosophical about that. \u201cIt\u2019s a crap shoot,\u201d he shrugged.<\/p>\n<h3><strong>Recovery, then a roadblock<\/strong><\/h3>\n<p>He figures that joining the trial was worth a try. He said he\u2019s had discussions with his cardiologist at Memorial about a heart transplant \u2013 he\u2019s not eligible \u2013 and an LVAD, which he doesn\u2019t need yet. Meanwhile, he said he works closely with <a href=\"https:\/\/www.uchealth.org\/provider\/heather-westenburg-np-cardiology\/\">Heather Westenburg<\/a>, a cardiology advanced practice provider with the <a href=\"https:\/\/www.uchealth.org\/locations\/uchealth-cardiology-memorial-hospital-central\/\">Heart Center at UCHealth Memorial Hospital<\/a>, to improve his overall health. That includes using a CPAP (continuous positive airway pressure) machine to treat his sleep apnea and controlling his diabetes with medications. Hagerstrom said he also exercises regularly at the YMCA with the aim of dropping some weight from his 245-pound frame.<\/p>\n<p>An Air Force veteran, Hagerstrom retired in 1988 and worked a series of jobs, including golf course grounds maintenance, in the years leading up to his heart attack \u2013 during which he admits he ignored warning signs like chest pain and shortness of breath. The problems caught up with him one night in late December while he worked at his computer. He said he knew immediately that the pain ripping through his chest was a heart attack. He called 911 and was rushed to Memorial, where a cardiologist opened his blocked artery with a stent. Three days later, he had his quadruple bypass surgery and celebrated New Year\u2019s Day 2004 in the intensive care unit.<\/p>\n<figure id=\"attachment_20390\" aria-describedby=\"caption-attachment-20390\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-20390\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124559\/EXT_121818_John-Messenger.jpgeee-1.webp\" alt=\"Dr. John Messenger performed the CardiAMP procedure on Hagerstrom October 30.\" width=\"300\" height=\"284\" srcset=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124559\/EXT_121818_John-Messenger.jpgeee-1.webp 395w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124559\/EXT_121818_John-Messenger.jpgeee-1-300x284.webp 300w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124559\/EXT_121818_John-Messenger.jpgeee-1-150x142.webp 150w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124559\/EXT_121818_John-Messenger.jpgeee-1-200x189.webp 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-20390\" class=\"wp-caption-text\">Dr. John Messenger performed the CardiAMP procedure on Hagerstrom October 30.<\/figcaption><\/figure>\n<p>Hagerstrom said his recovery \u201cwent fine\u201d for nearly 15 years. \u201cIt slowed me down, but I could do gardening in the spring and fall and shoveling. It just took longer than if I hadn\u2019t had a heart attack. I managed with medications and I had no pain.\u201d<\/p>\n<p>That changed last June when he was struck by atrial fibrillation, an irregular heart rate. \u201cThat slowed me down completely,\u201d he said. \u201cIf I walked 10 feet I was out of breath.\u201d<\/p>\n<h3><strong>Groundbreaker<\/strong><\/h3>\n<p>After a hospitalization at Memorial and tests, he slowly recovered with medication, a defibrillator and help from Mazzola. During a later Heart Center visit, he learned about the CardiAMP study, piquing an occasional interest he\u2019d taken over the years in the potential benefits of stem cell therapy. He agreed to go to UCH to see if he qualified, which he did after a completing a series of imaging tests and blood work, wearing a heart monitor and submitting to the bone marrow biopsy.<\/p>\n<p>The biggest surprise of the actual procedure was seeing what he estimated as 20 people jammed into the cardiac catheterization lab to watch Messenger and his team do their work. \u201cI had no idea,\u201d Hagerstrom said, joking about his \u201ccelebrity\u201d status as the first patient at UCH to join the trial.<\/p>\n<p>While he awaits the results of the procedure \u2013 if any \u2013 Hagerstrom is taking an active role in the study. He attends <a href=\"https:\/\/www.uchealth.org\/today\/heart-success-university-changes-colorado-springs-mans-life\/\">Memorial\u2019s Heart Failure University<\/a>, a free course designed to educate heart failure patients about managing their disease. In December he talked to attendees about his experiences with the CardiAMP study.<\/p>\n<p>\u201cI\u2019m a recruiter now,\u201d Hagerstrom said with a chuckle. \u201cI have a feeling I\u2019ll be doing more than one of these talks.\u201d<\/p>\n<p>Hagerstrom isn\u2019t the only one with a personal interest in the trial. Messenger\u2019s late father, who was a cardiologist for 40 years in Long Beach, California, participated in an early-phase cardiac stem cell trial at Scripps Health in 2010.<\/p>\n<p>\u201cHe realized there could be other options for heart failure treatment, so he was willing to be an early clinical trial participant,\u201d Messenger said. \u201cIt\u2019s been an interest of ours in the interventional cardiology realm for some time to try to figure out if there are things we could do to deliver stem cells that could heal the heart.\u201d<\/p>\n<p>As for Altman, she said she\u2019s hopeful that the trial will produce evidence that stem cell therapy can improve the quality of life for heart failure patients without having to resort to more invasive and disruptive interventions.<\/p>\n<p>\u201cI work in the world of LVADs and heart transplants,\u201d she said. \u201cUsing patients\u2019 own stem cells for treatment could be a wonderful option.\u201d<\/p>\n<p><em>Patients who are interested in the CardiAMP trial should contact Alisha Shudy, Professional Research Assistant: <\/em><a href=\"mailto:alisha.shudy@ucdenver.edu\"><em>alisha.shudy@ucdenver.edu<\/em><\/a><em>. Referring providers should contact Natasha Altman: <\/em><a href=\"mailto:natasha.altman@ucdenver.edu\"><em>natasha.altman@ucdenver.edu<\/em><\/a><em>.<\/em><\/p>\n<p><em>\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the waning days of 2003, Pete Hagerstrom suffered a heart attack that required quadruple bypass surgery at Memorial Hospital in Colorado Springs (now part of UCHealth). That was a life-changing event for him, of course, as it was for many others in 2003. Nearly 400,000 people in the United States had coronary artery bypass [&hellip;]<\/p>\n","protected":false},"author":2143,"featured_media":20391,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[84,3512,82,811,9167,4804],"class_list":["post-20387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-cardiology","tag-heart-and-vascular-care-cardiovascular","tag-heart-and-vascular-care-cardiology","tag-heart-disease","tag-specialized-services","tag-stem-cell"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can stem cells heal heart failure damage? - UCHealth Today<\/title>\n<meta name=\"description\" content=\"UCHealth is part of a trial to test the effectiveness of therapy that uses a patient\u2019s own stem cells to treat heart failure.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uchealth.org\/today\/can-stem-cells-heal-heart-failure-damage\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can stem cells heal heart failure damage?\" \/>\n<meta property=\"og:description\" content=\"UCHealth is part of a trial to test the effectiveness of therapy that uses a patient\u2019s own stem cells to treat heart failure.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uchealth.org\/today\/can-stem-cells-heal-heart-failure-damage\/\" \/>\n<meta property=\"og:site_name\" content=\"UCHealth Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uchealthorg\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-01-17T19:57:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-17T19:35:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2019\/01\/17124917\/featurephoto.jpg\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Tyler Smith\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uchealth\" \/>\n<meta name=\"twitter:site\" content=\"@uchealth\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tyler Smith\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/\"},\"author\":{\"name\":\"Tyler Smith\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/98c85c0e40c4933eedcec2cd054f349d\"},\"headline\":\"Can stem cells heal heart failure damage?\",\"datePublished\":\"2019-01-17T19:57:43+00:00\",\"dateModified\":\"2024-07-17T19:35:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/\"},\"wordCount\":1596,\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2019\\\/01\\\/17124917\\\/featurephoto.webp\",\"keywords\":[\"Cardiology\",\"Heart and vascular care\",\"Heart care\",\"heart disease\",\"Specialized services\",\"Stem cell\"],\"articleSection\":[\"Innovative care\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-stem-cells-heal-heart-failure-damage\\\/\",\"name\":\"Can stem cells heal heart failure damage? 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