{"id":4848,"date":"2016-03-23T00:00:00","date_gmt":"2016-03-23T06:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2016\/03\/23\/long-term-study-aims-to-connect-alzheimers-dots\/"},"modified":"2019-02-05T08:13:48","modified_gmt":"2019-02-05T15:13:48","slug":"long-term-study-aims-to-connect-alzheimers-dots","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/long-term-study-aims-to-connect-alzheimers-dots\/","title":{"rendered":"Long-term study aims to connect Alzheimer\u2019s dots"},"content":{"rendered":"
<\/div>

The Rocky Mountain Alzheimer\u2019s Disease Center at the Anschutz Medical Campus has launched a study so far-reaching that it hopes to help answer not only some of today\u2019s biggest questions relating to the disease, but also ones that Alzheimer\u2019s and other memory-disorder researchers have yet to formulate.<\/p>\n

\u201cThe whole goal is to be able to predict who\u2019s at risk before there are any clinical symptoms,\u201d said Huntington Potter, PhD, the RMADC\u2019s director.<\/p>\n

Brianne Bettcher, PhD, a neuropsychologist with the Rocky Mountain Alzheimer\u2019s Disease Center at the University of Colorado, is helping lead a long-term study to understand the roots and development of Alzheimer\u2019s disease.<\/figcaption><\/figure>\n

The Longitudinal Biomarker and Clinical Phenotyping Study<\/a>, launched in January, follows a line of inquiry that has become an RMADC calling card<\/a>: to better understand two very different but in fact closely related conditions \u2013 Alzheimer\u2019s disease and Down syndrome \u2013 through the strategic study of both under one roof.<\/p>\n

The study itself aims to establish a repository of blood, cerebral spinal fluid, imaging and clinical data from about 400 patients over the course of five years. Brianne Bettcher, PhD, a CU School of Medicine neuropsychologist, is leading the study as well as neuropsychology research at the RMADC.<\/p>\n

\u201cAs a neuropsychologist, I\u2019m very interested in assessing patients\u2019 cognition over time and relating it to their brain and physiological states,\u201d Bettcher said.<\/p>\n

The Memory Disorders Clinic at the UCHealth\u00a0University of Colorado Hospital Neurosciences Center <\/a>will serve as the study\u2019s main source of consenting patients, Bettcher says. CU neurologist Jonathan Woodcock, MD, who serves as the clinic\u2019s as well as the RMADC\u2019s clinical director, is a study co-investigator, as is Potter.<\/p>\n

One of four<\/strong><\/h2>\n

Bettcher and colleagues are enrolling four types of patients in the study: those who are healthy, those with mild cognitive impairment, those with Alzheimer\u2019s disease, and adults with Down syndrome. They hope to recruit and study roughly 100 people from each category over time, Bettcher says. Patients who join the study will undergo an annual evaluation, including cognitive testing, a physical and neurological exam, a brain MRI, bloodwork and the option of a cerebral spinal fluid draw, Bettcher says. While the study aims to advance science in the long-term, the workups may also identify treatable health problems that crop up with patients, she adds.<\/p>\n

On the scientific front, Bettcher aims to link long-term changes in factors such as blood proteins not only to Alzheimer\u2019s disease, but also to other cognitive disorders, vascular diseases and more, she says. The long-term evolution of a given patient\u2019s brain scans could offer clues as to the timing of disease onset, which probably happens well before cognitive symptoms manifest, she says.<\/p>\n

Part of what drives the need for the new study is that the amyloid beta plaques linked so strongly to Alzheimer\u2019s disease remain an imperfect proxy. Some people have a lot of amyloid beta in their brains but no symptoms for years; others with lesser amounts of plaque have severe cognitive impairment.<\/p>\n

\u201cHunt and I are very interested in understanding the heterogeneity,\u201d Bettcher said. \u201cAre there things that reflect resilience in the face of pathology, and how can we better predict that? Are there lifestyle factors that predict resilience with respect to Alzheimer\u2019s disease?\u201d<\/p>\n

Potter is also interested in studying the ApoE genes \u2013 certain forms of which boost Alzheimer\u2019s disease risk \u2013 from DNA collected from the samples\u2019 white blood cells. But both he and Bettcher stressed that the samples they collect will help future scientists answer questions that crop up well after today\u2019s inquiries have answers.<\/p>\n

\u201cWe\u2019re trying to be thoughtful about what we capture,\u201d Bettcher said. \u201cIt definitely requires some forethought about what you think you\u2019re going to need.\u201d<\/p>\n

High stakes<\/strong><\/h2>\n

The stakes \u2013 both personal and societal \u2013 in getting answers to such questions are enormous. In 2014, Alzheimer\u2019s disease was the sixth-leading cause of death, according to the U.S. Centers for Disease Control and Prevention. About 5.3 million people in the United States had Alzheimer\u2019s disease in 2015, and it and other dementias cost about $226 billion, according to<\/a> the Alzheimer\u2019s Association. Without a medical breakthrough, those numbers are expected to rise to about 14 million patients and $1.1 trillion by 2050, the Association says.<\/p>\n

For Bettcher, who arrived at CU from a faculty position at the University of California San Francisco in 2015, the study augments her work with the UCH Memory Disorders Clinic, where she sees patients one day a week. That\u2019s especially important in Colorado and surrounding states, where Alzheimer\u2019s is common and care is lacking, she adds.<\/p>\n

\u201cIt takes a special team to work this context. You\u2019re working with people during a potentially very vulnerable time in their lives,\u201d Bettcher said.”We are all very passionate about this work.”<\/p>\n

She and others on the team hope the new study and others at the RMADC help bring answers \u2013 and therapies based on them \u2013 to a disease that has yielded little to science.<\/p>\n

For more information on the study or the UCH Memory Disorders Clinic, contact the Neurosciences Center at 720.848.2080<\/span>.
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The Rocky Mountain Alzheimer\u2019s Disease Center at the Anschutz Medical Campus has launched a study so far-reaching that it hopes to help answer not only some of today\u2019s biggest questions relating to the disease, but also ones that Alzheimer\u2019s and other memory-disorder researchers have yet to formulate. \u201cThe whole goal is to be able to […]<\/p>\n","protected":false},"author":23,"featured_media":2437,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[7],"tags":[185,335],"class_list":["post-4848","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stories","tag-alzheimers-care","tag-anschutz-medical-campus"],"acf":[],"yoast_head":"\nLong-term study aims to connect Alzheimer\u2019s dots - 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