{"id":4973,"date":"2015-12-15T00:00:00","date_gmt":"2015-12-15T07:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2015\/12\/15\/one-small-chip-one-giant-step-toward-sight\/"},"modified":"2026-04-02T15:30:22","modified_gmt":"2026-04-02T21:30:22","slug":"one-small-chip-one-giant-step-toward-sight","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/one-small-chip-one-giant-step-toward-sight\/","title":{"rendered":"One small chip, one giant step toward sight"},"content":{"rendered":"<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div><figure id=\"attachment_1993\" aria-describedby=\"caption-attachment-1993\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1993 size-medium\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-scaled.webp\" width=\"300\" height=\"200\" srcset=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-scaled.webp 1600w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-300x200.webp 300w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-1024x683.webp 1024w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-768x512.webp 768w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-1536x1024.webp 1536w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-2048x1365.webp 2048w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-150x100.webp 150w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Oliver20Glasses-200x133.webp 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-1993\" class=\"wp-caption-text\">Scott Oliver, MD, chief of the Retinal Service at the UCHealth Eye Center, fits special glasses that are part of the Argus II system on patient Jamie Carley Dec. 4.<\/figcaption><\/figure>\n<p>On a sun-splashed morning, Jamie Carley sat on a couch facing a brightly lit window in a waiting area on the east side of the UCHealth Eye Center. Two Eye Center physicians, <a href=\"https:\/\/www.cudoctors.com\/Find_A_Doctor\/Profile\/1096\">Naresh Mandava, MD<\/a>, and <a href=\"https:\/\/www.cudoctors.com\/Find_A_Doctor\/Profile\/12888\">Scott Oliver, MD<\/a>, flanked her. Her mother, son, sister, and cousin stood nearby, looking on with a mixture of anticipation and anxiety.<\/p>\n<p>When she arrived at the Eye Center a short time earlier on this December day, Carley, 51, had worn dark glasses. She now wore a different kind of glasses \u2013 still dark, but equipped to help restore a small measure of something she lost many years ago: her vision.<\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145239\/EXT_121615_Window202-scaled.webp\" alt=\"Carley describes what she sees\" width=\"300\" height=\"200\" \/><figcaption class=\"wp-caption-text\">Oliver (right) and UCH Eye Center Medical Director Naresh Mandava, MD (partially obscured), ask Carley to describe what she sees.<\/figcaption><\/figure>\n<p>Carley suffers from retinitis pigmentosa, a disease that progressively damages the cells in the retina, called photoreceptors, that receive the light that is ultimately transformed to visual information in the brain. The glasses she wore are part of the Argus II Retinal Prosthesis System (Argus II), which includes a microchip implanted in the eye. Carley is the first patient in the Rocky Mountain region to complete the procedure, led by Mandava and Oliver.<\/p>\n<p>That\u2019s right: Carley now has a bionic eye.<\/p>\n<p>The microchip, which Mandava and Oliver sutured to the surface of Carley\u2019s right eye, contains an array of 60 electrodes with an antenna. The special glasses are outfitted with a camera that receives images and transmits them to a video processor Carley and other Argus II patients carry. The processor transforms the images into instructions \u2013 areas of light and dark, for example \u2013 and sends them back to the glasses.<\/p>\n<p>The glasses then wirelessly transmit the information to the antenna in the implant, which sends it on to the electrodes on the retina. The electrodes fire, stimulating the small number of remaining undamaged retinal cells, which relay information via the optic nerve to the brain. The brain converts the signals to gray-scale images \u2013 nothing like normal vision, but a semblance of the long-unseen world.<\/p>\n<p><strong>The long view<\/strong><\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145238\/EXT_121615_John20Window-scaled.webp\" alt=\"Carley and John\" width=\"300\" height=\"282\" \/><figcaption class=\"wp-caption-text\">Carley gazes at her son Jon as he stands at the window.<\/figcaption><\/figure>\n<p>The sophisticated technology has been more than two decades in the making, Mandava said. For Carley, Argus II is a conduit to her most basic desires. By the time she was 17, her vision had deteriorated to the point she needed adaptive equipment. She has only childhood memories of watching with her family as fireworks exploded in colors above a lake in Kansas. She knows her son Jon, 29, by sound, not by sight.<\/p>\n<p>\u201cThe first thing I want to lay my eyes on is my son,\u201d she said in the days before the device was turned on. \u201cI remember glimpses of him growing up, but I don\u2019t know if it\u2019s what I really saw or what I imagined.\u201d<\/p>\n<p>After months of working with a team that includes Mandava, Oliver, professional research assistant Mary Preston, and Cynthia Cruz, a clinical representative from Second Sight, which manufactures the Argus II device, Carley had realistic expectations of what the Argus II could do. Seeing shadows, doorways, window frames, or a person walking toward her would be \u201ca gift\u201d after decades in darkness, she said.<\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145238\/EXT_121615_Mother20Window-scaled.webp\" alt=\"Carley's mother\" width=\"300\" height=\"200\" \/><figcaption class=\"wp-caption-text\">Carley\u2019s mother tries to contain her emotions as she takes her turn at the window.<\/figcaption><\/figure>\n<p>Her practical view and determination are major advantages, Cruz said in the moments before Carley donned the Argus II glasses.<\/p>\n<p>\u201cThe device needs a participating patient who works hard,\u201d Cruz said. \u201cI think that\u2019s right up her alley.\u201d<\/p>\n<p>Her family could second that. Sitting together at the Eye Center shortly before the big test, they talked about Carley\u2019s determination to adapt to her blindness.<\/p>\n<p>\u201cShe knew all the bumps in the road when we drove,\u201d her sister Kim recalled. \u201cShe\u2019d say, \u2018Mom, you missed that turn.\u2019 \u201d<\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145237\/EXT_121615_Jamie20Hand-scaled.webp\" alt=\"testing the device\" width=\"300\" height=\"278\" \/><figcaption class=\"wp-caption-text\">Jamie brings her hand close to test the device. Mary Preston, a professional research assistant with Ophthalmology, and Cynthia Cruz, clinical representative for Argus II manufacturer Second Sight look on.<\/figcaption><\/figure>\n<p>Jon recalled his mother having him wear a blindfold to understand the reality of lost sight. \u201cEating Chinese food was the worst,\u201d he said. \u201cRice all over the table, and you didn\u2019t know.\u201d<\/p>\n<p><strong>The first step of many<\/strong><\/p>\n<p>That lesson underscored the importance of adjusting to change \u2013 the fundamental theme of Carley\u2019s life. The disease took her vision in stages, with peripheral, night, and central vision gradually fading. Finally, even colors were gone; only an annoying brightness in the left eye remained.<\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145236\/EXT_121615_Jamie20John20Outside-scaled.webp\" alt=\"Outside the eye center\" width=\"300\" height=\"235\" \/><figcaption class=\"wp-caption-text\">Mandava and Carley, outside the Eye Center, with Jon.<\/figcaption><\/figure>\n<p>\u201cAt every stage, I had to learn to adapt,\u201d she said.<\/p>\n<p>Now it is on to another stage of adaptation. The bionic eye doesn\u2019t deliver even rudimentary vision at the simple flip of a switch. Carley will need extensive rehabilitation to train her brain to interpret the signals the device transmits. She will also continue to rely on the skills she developed to help her navigate the unseen world, Mandava said.<\/p>\n<p>\u201cShe will still use tactile cues and memories of the space she lives in and works around,\u201d he said.<\/p>\n<p>But Cruz said she saw encouraging signs nearly as soon as Carley looked through the new glasses.<\/p>\n<p>\u201cFrom the moment we turned the device on, she instinctively started scanning left to right,\u201d Cruz said. The movements were a sign that Carley was looking for the corner of the bright window. Cruz was similarly encouraged when Carley stepped out of the waiting room for a short walk along the east side of the Eye Center. She tucked in her chin, looking down to make out the contrast of dark grass against snow on the north side of the Eye Center. Mandava also noted Carley\u2019s awareness of movement when a car drove past on 17th Avenue.<\/p>\n<p><strong>The payoff<\/strong><\/p>\n<p>Those practical successes, however, faded in comparison to several poignant moments a few minutes earlier. Sitting on the couch inside, with Mandava\u2019s arm around her and Oliver holding a laptop computer that displayed the images from the video processor, Jon positioned himself in front of the window.<\/p>\n<p>Mandava instructed Carley to look for an edge to the white square as she slowly moved her head. The laptop screen showed a silhouetted figure.<\/p>\n<figure style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28145235\/EXT_121615_Jamie20Street-scaled.webp\" alt=\"Argus II\" width=\"300\" height=\"242\" \/><figcaption class=\"wp-caption-text\">Carley tests the Argus II at the north end of the Eye Center as Mandava watches.<\/figcaption><\/figure>\n<p>\u201cWho is that?\u201d Carley asked.<\/p>\n<p>\u201cShe senses me; she doesn\u2019t have to see me,\u201d Jon said.<\/p>\n<p>Carley\u2019s mother was next, then Kim, each of them standing near the window. Carley looked ahead raptly, slowly moving her head. \u201cYou\u2019re tracking perfectly,\u201d Mandava said. Soon it was his turn at the window, where he joined Kim and Wendy, the sisters\u2019 cousin.<\/p>\n<p>\u201cThat\u2019s Dr. Mandava,\u201d someone said. \u201cYou\u2019ve never seen him before.\u201d Mandava appeared on the laptop screen as the tallest of the three silhouettes.<\/p>\n<p>\u201cI really had to go up for that one,\u201d Carley said.<\/p>\n<p>Her spirits also rose, along with those of her family.<\/p>\n<p>Asked whether the morning had been all she hoped for, Carley\u2019s mother had a ready reply.<\/p>\n<p>\u201cAll that,\u201d she said, \u201cand more.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>On a sun-splashed morning, Jamie Carley sat on a couch facing a brightly lit window in a waiting area on the east side of the UCHealth Eye Center. Two Eye Center physicians, Naresh Mandava, MD, and Scott Oliver, MD, flanked her. Her mother, son, sister, and cousin stood nearby, looking on with a mixture of [&hellip;]<\/p>\n","protected":false},"author":2143,"featured_media":1993,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[848,427,3631],"class_list":["post-4973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-eye-care-ophthalmology","tag-opthalmology","tag-uchealth-sue-anschutz-rodgers-eye-center"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>One small chip, one giant step toward sight - UCHealth Today<\/title>\n<meta name=\"description\" content=\"On a sun-splashed morning, Jamie Carley sat on a couch facing a brightly lit window in a waiting area on the east side of the UCHealth Eye Center. Two Eye Center physicians, Naresh Mandava, MD, and Scott Oliver, MD, flanked her. Her mother, son, sister, and cousin stood nearby, l...\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"One small chip, one giant step toward sight\" \/>\n<meta property=\"og:description\" content=\"On a sun-splashed morning, Jamie Carley sat on a couch facing a brightly lit window in a waiting area on the east side of the UCHealth Eye Center. Two Eye Center physicians, Naresh Mandava, MD, and Scott Oliver, MD, flanked her. 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