{"id":66111,"date":"2022-10-06T10:16:45","date_gmt":"2022-10-06T16:16:45","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=66111"},"modified":"2024-07-17T16:04:04","modified_gmt":"2024-07-17T22:04:04","slug":"rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/","title":{"rendered":"RNA experts have dengue, zika, West Nile vaccines in their sights"},"content":{"rendered":"
<\/div>
\"Saral
Sarah Leach at a microscope in the closed-door section of the lab where the team works with live zika, West Nile, and other viruses, to find commonalities and ultimately, lead the way for new vaccines. Photos by Cyrus McCrimmon, for UCHealth.<\/figcaption><\/figure>\n

Dengue may not be a top-of-mind malady for those in Colorado, but it infects about 400 million people<\/a> worldwide each year \u2013 roughly four times the official cumulative U.S. coronavirus case count. West Nile virus put several people in UCHealth University of Colorado Hospital<\/a> at the Anschutz Medical Campus<\/a> (UCH) this summer. Zika remains a threat in the Americas and beyond.<\/p>\n

These are different viruses, but they belong to a class of about 70 flaviruses<\/a> in the crosshairs of an eight-person research group led by University of Colorado School of Medicine infectious disease specialist and UCHealth physician Dr. David Beckham<\/a>. Their aim is to genetically engineer a skeleton key to unlock an entire class of viruses to the rapid-fire creation of vaccines as these flaviviruses inevitably mutate \u2013 and they mutate faster than even flu viruses do. The work in their lab on the eighth floor of Research Complex 1 could one day improve the lives of millions of people the world over.<\/p>\n

\"From
From left, Beckham Lab team members Haider Ali, postdoctoral research fellow; Sarah Leach, microbiology PhD student; Dillon Donaghy, biomedical sciences PhD student; Dr. David Beckham; Imali Kegode, microbiology master\u2019s student; and Kelsey Lesteberg, CU School of Medicine Infectious Diseases instructor.<\/figcaption><\/figure>\n

The flavivirus family: West Nile virus, zika, dengue and yellow fever<\/strong><\/h2>\n

Beckham, who sees inpatients through the infectious disease service at UCH, has won major National Institutes of Health grants to move the work forward. The idea, he says, is finding commonalities that run across the flavivirus family\u2019s RNA genome and make changes such that the viruses are strong enough to replicate but too weak to multiply themselves enough to cause infection.<\/p>\n

Doing so could open the doors to new live attenuated vaccines<\/a> that prep the immune system for the invasion of a more dangerous virus. In Marvel Cinematic Universe terms, it\u2019s about genetically engineering a Bruce Banner virus to gird the immune system for a wild-type<\/a> Hulk virus. (MMR, varicella, rotavirus, and intranasal influenza vaccines are examples of live attenuated vaccines available today.)<\/p>\n

\u201cThat\u2019s the big push in the field: to come up with these broad-based platforms where we can swap genes in and out and quickly come up with a vaccine for newly emerging viruses,\u201d Beckham said.<\/p>\n

Cells to mice to humans<\/strong><\/h2>\n

The team is making progress, he says, but this is basic research, and it\u2019s going to take time. At the moment, the team is focusing mainly on reengineering Zika viruses with a focus on genes in the 3\u2019 (\u201cthree-prime\u201d) untranslated region<\/a> at the tail end of the flavivirus\u2019s genome. This region doesn\u2019t encode viral proteins as such but appears to help the virus evade mammalian immune systems.<\/p>\n

Beckham\u2019s team has shown that Zika viruses weakened through their gene edits brought about immune responses in mouse and human cell cultures, and they\u2019ve moved on to see how the immune systems of mice react to these attenuated viruses. Once effectiveness and safety have been established in mice, they\u2019ll move on to experimental drug approval by the U.S Food and Drug Administration. That will set the table for a human phase 1 clinical trial<\/a> to establish its safety, which could happen in two to three years, Beckham estimates.<\/p>\n

\"Kelsey
Kelsey Lesteberg, a CU School of Medicine microbiology Ph.D. student, in the Beckham lab. Lesteberg is part of a research team that aims at finding a vaccine for West Nile virus and other flaviviruses.<\/figcaption><\/figure>\n

In the meantime, his team is also pursuing variations on their established themes. CU School of Medicine microbiology Ph.D. student Sarah Leach is, as she put it \u201cessentially gluing two viruses together,\u201d in this case by combining the RNA that encodes the proteins that create the envelope of a dengue virus with the nonstructural proteins of a Zika virus tweaked in that 3\u2019 region. She\u2019ll then see if the chimeric (mixed) and weakened virus can protect from dengue virus infections.<\/p>\n

\u201cSo I combine those two parts, the dengue virus structural part and the Zika virus nonstructural part, and then hopefully come up with a platform to make a live attenuated RNA vaccine for dengue virus,\u201d Leach said.<\/p>\n

That wasn\u2019t easy to say, and it won\u2019t be easy to do. The effort will take years and ideally earn her that Ph.D. along the way. Leach says she\u2019s ready for the challenge. She loves the process of thinking through what might work better and learning from the false starts and dead ends inevitable in the scientific process. But she and her colleagues are also clear on the potential impact of their work.<\/p>\n

Climate change is expanding the range of the Aedes<\/em> species of mosquito that spreads dengue, for example. The disease is a risk to 40% of the world\u2019s population today experts believe that will rise<\/a> to 60% by 2080 as the planet warms.<\/p>\n

\u201cI think we as a society have put these viruses on the back burner because they don\u2019t affect people in the United States and Europe as often,\u201d Leach said. \u201cBut this is a threat that is coming for us, and we have to be prepared.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Dengue may not be a top-of-mind malady for those in Colorado, but it infects about 400 million people worldwide each year \u2013 roughly four times the official cumulative U.S. coronavirus case count. West Nile virus put several people in UCHealth University of Colorado Hospital at the Anschutz Medical Campus (UCH) this summer. Zika remains a […]<\/p>\n","protected":false},"author":23,"featured_media":66115,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[162,4781],"class_list":["post-66111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-infectious-diseases","tag-research-in-health-care"],"acf":[],"yoast_head":"\nRNA experts have dengue, zika, West Nile vaccines in their sights - UCHealth Today<\/title>\n<meta name=\"description\" content=\"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RNA experts have dengue, zika, West Nile vaccines in their sights\" \/>\n<meta property=\"og:description\" content=\"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/\" \/>\n<meta property=\"og:site_name\" content=\"UCHealth Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uchealthorg\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-06T16:16:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-17T22:04:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.jpg\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Todd Neff, for UCHealth\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uchealth\" \/>\n<meta name=\"twitter:site\" content=\"@uchealth\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Todd Neff, for UCHealth\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/\"},\"author\":{\"name\":\"Todd Neff, for UCHealth\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/da7733ff5562e48e55c027d111ee5911\"},\"headline\":\"RNA experts have dengue, zika, West Nile vaccines in their sights\",\"datePublished\":\"2022-10-06T16:16:45+00:00\",\"dateModified\":\"2024-07-17T22:04:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/\"},\"wordCount\":926,\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2022\\\/10\\\/06093834\\\/Beckham-lab-Sarah-Leach-microscope.webp\",\"keywords\":[\"Infectious diseases\",\"Research in health care\"],\"articleSection\":[\"Innovative care\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/\",\"name\":\"RNA experts have dengue, zika, West Nile vaccines in their sights - UCHealth Today\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2022\\\/10\\\/06093834\\\/Beckham-lab-Sarah-Leach-microscope.webp\",\"datePublished\":\"2022-10-06T16:16:45+00:00\",\"dateModified\":\"2024-07-17T22:04:04+00:00\",\"description\":\"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#primaryimage\",\"url\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2022\\\/10\\\/06093834\\\/Beckham-lab-Sarah-Leach-microscope.webp\",\"contentUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2022\\\/10\\\/06093834\\\/Beckham-lab-Sarah-Leach-microscope.webp\",\"width\":1200,\"height\":827,\"caption\":\"Saral Leach at a microscope in the closed-door section of the lab in which the team works with live zika, dengue, and other viruses.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"RNA experts have dengue, zika, West Nile vaccines in their sights\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#website\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\",\"name\":\"UCHealth Today\",\"description\":\"UCHealth Today\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\",\"name\":\"UCHealth\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/04\\\/24135149\\\/UCHealth-square-logo-1000x1000-1.jpg\",\"contentUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/04\\\/24135149\\\/UCHealth-square-logo-1000x1000-1.jpg\",\"width\":1000,\"height\":1000,\"caption\":\"UCHealth\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/uchealthorg\\\/\",\"https:\\\/\\\/x.com\\\/uchealth\",\"https:\\\/\\\/www.instagram.com\\\/uchealth\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/14839\\\/\",\"https:\\\/\\\/www.pinterest.com\\\/uchealthorg\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC41SJI79yjZIe96OajzN22g\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/da7733ff5562e48e55c027d111ee5911\",\"name\":\"Todd Neff, for UCHealth\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g\",\"caption\":\"Todd Neff, for UCHealth\"},\"description\":\"Todd Neff has written hundreds of stories for University of Colorado Hospital and UCHealth. He covered science and the environment for the Daily Camera in Boulder, Colorado, and has taught narrative nonfiction at the University of Colorado, where he was a Ted Scripps Fellowship recipient in Environmental Journalism. He is author of \u201cA Beard Cut Short,\u201d a biography of a remarkable professor; \u201cThe Laser That\u2019s Changing the World,\u201d a history of lidar; and \u201cFrom Jars to the Stars,\u201d a history of Ball Aerospace.\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/author\\\/tneff\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"RNA experts have dengue, zika, West Nile vaccines in their sights - UCHealth Today","description":"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/","og_locale":"en_US","og_type":"article","og_title":"RNA experts have dengue, zika, West Nile vaccines in their sights","og_description":"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.","og_url":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/","og_site_name":"UCHealth Today","article_publisher":"https:\/\/www.facebook.com\/uchealthorg\/","article_published_time":"2022-10-06T16:16:45+00:00","article_modified_time":"2024-07-17T22:04:04+00:00","og_image":[{"url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.jpg","type":"image\/jpeg"}],"author":"Todd Neff, for UCHealth","twitter_card":"summary_large_image","twitter_creator":"@uchealth","twitter_site":"@uchealth","twitter_misc":{"Written by":"Todd Neff, for UCHealth","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#article","isPartOf":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/"},"author":{"name":"Todd Neff, for UCHealth","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/person\/da7733ff5562e48e55c027d111ee5911"},"headline":"RNA experts have dengue, zika, West Nile vaccines in their sights","datePublished":"2022-10-06T16:16:45+00:00","dateModified":"2024-07-17T22:04:04+00:00","mainEntityOfPage":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/"},"wordCount":926,"publisher":{"@id":"https:\/\/www.uchealth.org\/today\/#organization"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#primaryimage"},"thumbnailUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.webp","keywords":["Infectious diseases","Research in health care"],"articleSection":["Innovative care"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/","url":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/","name":"RNA experts have dengue, zika, West Nile vaccines in their sights - UCHealth Today","isPartOf":{"@id":"https:\/\/www.uchealth.org\/today\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#primaryimage"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#primaryimage"},"thumbnailUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.webp","datePublished":"2022-10-06T16:16:45+00:00","dateModified":"2024-07-17T22:04:04+00:00","description":"Research at the CU School of Medicine aims to lead to the creation one day of vaccines for dengue, zika and West Nile viruses.","breadcrumb":{"@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#primaryimage","url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.webp","contentUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/10\/06093834\/Beckham-lab-Sarah-Leach-microscope.webp","width":1200,"height":827,"caption":"Saral Leach at a microscope in the closed-door section of the lab in which the team works with live zika, dengue, and other viruses."},{"@type":"BreadcrumbList","@id":"https:\/\/www.uchealth.org\/today\/rna-experts-have-dengue-zika-west-nile-virus-vaccines-in-their-sights\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uchealth.org\/today\/"},{"@type":"ListItem","position":2,"name":"RNA experts have dengue, zika, West Nile vaccines in their sights"}]},{"@type":"WebSite","@id":"https:\/\/www.uchealth.org\/today\/#website","url":"https:\/\/www.uchealth.org\/today\/","name":"UCHealth Today","description":"UCHealth Today","publisher":{"@id":"https:\/\/www.uchealth.org\/today\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uchealth.org\/today\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.uchealth.org\/today\/#organization","name":"UCHealth","url":"https:\/\/www.uchealth.org\/today\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/logo\/image\/","url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/04\/24135149\/UCHealth-square-logo-1000x1000-1.jpg","contentUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/04\/24135149\/UCHealth-square-logo-1000x1000-1.jpg","width":1000,"height":1000,"caption":"UCHealth"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uchealthorg\/","https:\/\/x.com\/uchealth","https:\/\/www.instagram.com\/uchealth\/","https:\/\/www.linkedin.com\/school\/14839\/","https:\/\/www.pinterest.com\/uchealthorg\/","https:\/\/www.youtube.com\/channel\/UC41SJI79yjZIe96OajzN22g"]},{"@type":"Person","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/person\/da7733ff5562e48e55c027d111ee5911","name":"Todd Neff, for UCHealth","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ba17a8f1358d39c104ff6cb59da7fe21b9bfc792948447c3ac964e93b37aa49f?s=96&d=mm&r=g","caption":"Todd Neff, for UCHealth"},"description":"Todd Neff has written hundreds of stories for University of Colorado Hospital and UCHealth. He covered science and the environment for the Daily Camera in Boulder, Colorado, and has taught narrative nonfiction at the University of Colorado, where he was a Ted Scripps Fellowship recipient in Environmental Journalism. He is author of \u201cA Beard Cut Short,\u201d a biography of a remarkable professor; \u201cThe Laser That\u2019s Changing the World,\u201d a history of lidar; and \u201cFrom Jars to the Stars,\u201d a history of Ball Aerospace.","url":"https:\/\/www.uchealth.org\/today\/author\/tneff\/"}]}},"coauthors":[{"id":23,"name":"Todd Neff","link":"https:\/\/www.uchealth.org\/today\/author\/tneff\/"}],"_links":{"self":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/66111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/comments?post=66111"}],"version-history":[{"count":10,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/66111\/revisions"}],"predecessor-version":[{"id":76958,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/66111\/revisions\/76958"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/media\/66115"}],"wp:attachment":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/media?parent=66111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/categories?post=66111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/tags?post=66111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}