{"id":81412,"date":"2025-04-01T13:23:32","date_gmt":"2025-04-01T19:23:32","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=81412"},"modified":"2025-11-14T05:48:39","modified_gmt":"2025-11-14T12:48:39","slug":"unlocking-medical-and-personal-health-insights-with-biobanking","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/unlocking-medical-and-personal-health-insights-with-biobanking\/","title":{"rendered":"Unlocking medical and personal health insights with biobanking"},"content":{"rendered":"<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div><figure id=\"attachment_79844\" aria-describedby=\"caption-attachment-79844\" style=\"width: 640px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-79844\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2025\/01\/13080331\/CCPM-Biobank-1web.webp\" alt=\"A clinical lab technologist makes DNA dilutions before genetic testing at the Colorado Center for Personalized Medicine Biobank Laboratory. Photo: Sonya Doctorian.\" width=\"640\" height=\"410\" \/><figcaption id=\"caption-attachment-79844\" class=\"wp-caption-text\">A clinical lab technologist makes DNA dilutions before genetic testing at the Colorado Center for Personalized Medicine Biobank Laboratory. Photo: Sonya Doctorian.<\/figcaption><\/figure>\n<p>Genes play a big role in health, including the risk of developing certain diseases and the effectiveness of various medications.<\/p>\n<p>To receive personalized medical insights based on their genes, many patients are participating in the <a href=\"https:\/\/www.uchealth.org\/services\/biobank\/\">biobank at the Colorado Center for Personalized Medicine<\/a>, which is a partnership between UCHealth and the <a id=\"\" href=\"https:\/\/www.cuanschutz.edu\/\" target=\"_blank\" rel=\"noopener\">University of Colorado Anschutz Medical Campus<\/a>.<\/p>\n<p>After a patient enrolls, a sample of blood is taken and reviewed for genetic variations in about two million spots in the genome.<br \/>\n<div class=\"su-callout-box col-xs-12 col-sm-6 right\" style=\"background-color:#dce4e7; color:#2e3b44;\">\n<h4><strong>Participating in the biobank is easy. How to get started.<\/strong><\/h4>\n<ul>\n<li>Join the biobank by signing a consent form in your <a title=\"https:\/\/mychart.uchealth.org\/MYCHART\/Home\/LogOut?postloginurl=fdiredirect?webid=WP-24DrUuwClF4ynTbPmXC1i9PA-3D-3D-24EhON06K-2BLqQp50DkcIx9pHq8dYBDhlTG66G-2Fa-2BwyHc0-3D&amp;mobileaction=https%3A%2F%2Fexit.uchealth.org%2Fresearchopportunities\" href=\"https:\/\/mychart.uchealth.org\/MYCHART\/Home\/LogOut?postloginurl=fdiredirect?webid=WP-24DrUuwClF4ynTbPmXC1i9PA-3D-3D-24EhON06K-2BLqQp50DkcIx9pHq8dYBDhlTG66G-2Fa-2BwyHc0-3D&amp;mobileaction=https%3A%2F%2Fexit.uchealth.org%2Fresearchopportunities\" target=\"_blank\" rel=\"noopener noreferrer\" data-outlook-id=\"bd8fd289-8289-4087-a39b-569294b465ba\" data-auth=\"NotApplicable\" data-linkindex=\"0\">My Health Connection Account.<\/a><\/li>\n<li>You must be a UCHealth patient who is age 18 or older.<\/li>\n<li>After you sign up, during an upcoming visit that requires a blood draw, a medical provider will collect an extra vial of blood for the biobank.<\/li>\n<li>Learn more about\u00a0<a title=\"https:\/\/www.uchealth.org\/services\/biobank\/\" href=\"https:\/\/www.uchealth.org\/services\/biobank\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-outlook-id=\"09067291-a022-44c7-a66c-6a892055e0d6\" data-auth=\"NotApplicable\" data-linkindex=\"1\">the biobank<\/a>.<\/li>\n<\/ul>\n<\/div>\n<p>Those <a href=\"https:\/\/www.uchealth.org\/today\/5-reasons-why-participate-in-biobank-at-colorado-center-for-personalized-medicine\/\">results help in two ways<\/a>. First, they allow researchers to learn more about diseases. For instance, teams are developing genetic models to help identify people at high risk for conditions such as diabetes and atrial fibrillation, which allows for early screening and preventative steps.<\/p>\n<figure id=\"attachment_64770\" aria-describedby=\"caption-attachment-64770\" style=\"width: 250px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-64770 size-full\" style=\"color: var(--color__text_main);font-family: var(--font__400)\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/07\/08143435\/Biobank-1-David-Kao.webp\" alt=\"Dr. David Kao\" width=\"250\" height=\"343\" srcset=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/07\/08143435\/Biobank-1-David-Kao.webp 250w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/07\/08143435\/Biobank-1-David-Kao-219x300.webp 219w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/07\/08143435\/Biobank-1-David-Kao-109x150.webp 109w, https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2022\/07\/08143435\/Biobank-1-David-Kao-200x274.webp 200w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><figcaption id=\"caption-attachment-64770\" class=\"wp-caption-text\">Dr. David Kao<\/figcaption><\/figure>\n<p><span style=\"margin: 0px;padding: 0px\">Secondly, results help patients by providing valuable information, such as which medications and dosages are most effective and\u00a0whether a patient is likely to develop certain treatable diseases.<\/span><\/p>\n<p>\u201cThat clinical part is unique,\u201d said <a href=\"https:\/\/www.uchealth.org\/provider\/david-kao-md\/\">Dr. David Kao<\/a>, the medical director of the Colorado Center for Personalized Medicine and an associate professor of medicine at the University of Colorado School of Medicine.\u00a0 \u201cWe have a very clinically active biobank, which is exciting and makes it more attractive for participants.\u201d<\/p>\n<h2><strong>Biobanking&#8217;s influence on medication types and dosages<\/strong><\/h2>\n<p>The genes analyzed give insights into how a wide range of medications \u2013 from cardiac and GI medications to <a id=\"\" href=\"https:\/\/www.uchealth.org\/today\/the-facts-and-misconceptions-about-antidepressant-medications\/\">antidepressants<\/a> and pain medications \u2013 will work for a patient. Abnormalities in these genes can signal that a patient might need a higher or lower dose of certain medications or a different type of medication altogether.<\/p>\n<p>Among UCHealth biobank participants, more than 90% have genetic variations that may affect their response to certain medications.<\/p>\n<p>\u201cThere are genetic variants that affect medications like ibuprofen or opiates, making them less or more effective,\u201d Kao said. \u201cIf someone takes pain medications and feels sick or sedated for days, they may be afraid to take anything. These results can show they just need to use a slightly different agent.\u201d<\/p>\n<p>The genetic analysis can also reveal optimal dosages for chemotherapy, which can significantly impact a patient\u2019s response to treatment.<\/p>\n<p>\u201cIf chemo levels are too high, you may have terrible side effects that keep you from treating the cancer. If they\u2019re too low, you\u2019re not treating your cancer,\u201d Kao said.<\/p>\n<p>With more than 73,000 patients receiving these results so far, UCHealth has the biggest program in the U.S. and perhaps in the world.<\/p>\n<p>\u201cWe\u2019ve already seen a lot of impact,\u201d Kao said. \u201cThousands of prescriptions have been changed because of it.\u201d<\/p>\n<p>The information is available in a patient\u2019s health record: when a provider selects a medication, they\u2019ll quickly see whether an alternative would be better.<\/p>\n<p>As new interactions are discovered, patients will continue to receive updated results, even if they have already submitted a sample.<\/p>\n<p>\u201cThey won\u2019t miss out if they\u2019re an early participant,\u201d Kao said.<\/p>\n<h2><strong>Biobanking&#8217;s impact on early detection of treatable diseases<\/strong><\/h2>\n<p>The genetic analysis also reviews dozens of genes for particular variants that can increase risk for life-altering or life-threatening diseases that are preventable or treatable. Those diseases include cancer, heart disease, diabetes, neurological conditions and more.<\/p>\n<p>While these findings are infrequent, they are impactful. For instance, if a predisposition for breast cancer is found, a patient may undergo early MRI breast cancer screening.<\/p>\n<p>\u201cWe\u2019ve had some really striking examples of how this has benefited not only the participant but their family too,\u201d Kao said.<\/p>\n<p>Through participating in the biobank, <a href=\"https:\/\/www.uchealth.org\/today\/mom-learned-of-genetic-risk-for-arvc-after-donating-her-blood-to-biobank\/\">one woman learned she had a genetic variant<\/a> associated with a heart problem that can cause cardiac arrest without warning. She consulted the appropriate specialists and started monitoring for warning signs to avoid potentially life-threatening episodes. She can now consider monitoring for her young children if needed.<\/p>\n<p>\u201cThis condition may be asymptomatic and only discovered after a patient has a cardiac arrest,\u201d Kao said. \u201cAwareness of this genetic variant can help avoid devastating events in any affected family members, including children and later generations.\u201d<\/p>\n<p>If a patient is shown to be at higher risk for developing one of the preventable or treatable diseases, a <a href=\"https:\/\/www.uchealth.org\/services\/genetic-testing-and-counseling\/\">genetic counselor<\/a> reaches out and determines whether the patient wants to be informed of the finding.<\/p>\n<p>While genetic testing is helpful, Kao emphasized that it\u2019s just one part of the picture.<\/p>\n<p>\u201cIt\u2019s like your blood count or how tall you are \u2013 it\u2019s something that comes into play sometimes, but it doesn\u2019t mean a certain thing is going to happen,\u201d Kao said. \u201cIt can be a really helpful and different way of keeping people healthy.\u201d<\/p>\n<p>Kao also emphasized that the biobank has made such strides thanks to the focus from UCHealth.<\/p>\n<p>\u201cThis all exists because UCHealth has made it a priority and has decided this is the future of what medicine will be,\u201d Kao said.<\/p>\n<p><em>This story first appeared in the Steamboat Pilot.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genes play a big role in health, including the risk of developing certain diseases and the effectiveness of various medications. To receive personalized medical insights based on their genes, many patients are participating in the biobank at the Colorado Center for Personalized Medicine, which is a partnership between UCHealth and the University of Colorado Anschutz [&hellip;]<\/p>\n","protected":false},"author":2163,"featured_media":79844,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[9085,1024,138],"class_list":["post-81412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-biobank","tag-blood-disorders-disease-care-hematology","tag-center-for-personalized-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Unlocking medical and personal health insights with biobanking - UCHealth Today<\/title>\n<meta name=\"description\" content=\"Biobanking aids disease understanding, helps develop genetic models for early screening and offers valuable, personal medical insights.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uchealth.org\/today\/unlocking-medical-and-personal-health-insights-with-biobanking\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unlocking medical and personal health insights with biobanking\" \/>\n<meta property=\"og:description\" content=\"Biobanking aids disease understanding, helps develop genetic models for early screening and offers valuable, personal medical insights.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uchealth.org\/today\/unlocking-medical-and-personal-health-insights-with-biobanking\/\" \/>\n<meta property=\"og:site_name\" content=\"UCHealth Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uchealthorg\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-01T19:23:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-14T12:48:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2025\/01\/13080331\/CCPM-Biobank-1web.jpg\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Susan Cunningham, for UCHealth\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uchealth\" \/>\n<meta name=\"twitter:site\" content=\"@uchealth\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Susan Cunningham, for UCHealth\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/unlocking-medical-and-personal-health-insights-with-biobanking\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/unlocking-medical-and-personal-health-insights-with-biobanking\\\/\"},\"author\":{\"name\":\"Susan Cunningham, for UCHealth\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/f2737182b44781de4109fdd5dd464270\"},\"headline\":\"Unlocking medical and personal health insights with biobanking\",\"datePublished\":\"2025-04-01T19:23:32+00:00\",\"dateModified\":\"2025-11-14T12:48:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/unlocking-medical-and-personal-health-insights-with-biobanking\\\/\"},\"wordCount\":952,\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/unlocking-medical-and-personal-health-insights-with-biobanking\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2025\\\/01\\\/13080331\\\/CCPM-Biobank-1web.webp\",\"keywords\":[\"Biobank\",\"Blood disorders &amp; 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